Investigation of the Biological Activity of Modified Branched Poly (P-Hydroxystyrene)

Document Type : Original Article

Authors

1 Chemistry Department, Faculty of Dentistry, Sinai University, Kantara, Egypt.

2 Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt

3 Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.

Abstract

The development of novel antimicrobial polymers is one of the most promising
methods for preventing the growth of germs and limiting the spread of infections in 
a range of applications. Modified polymers have attracted an interest in biological
activities. A series of modified poly (p-hydroxystyrene) was screened for in vitro 
antimicrobial activities against Gram-positive bacteria (Staphylococcus aureus),
Gram-negative bacteria (Escherichia coli) and fungi (Candida albicans). Through 
the utilization of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, the antioxidant
activities were examined. To evaluate each compound's affinity and binding pattern 
towardsthe E. coli protein active site, molecular docking was used. The modification 
was performed by chloroacetylation, then amination with 1,2-ethylenediamine and
finally, the Schiff base compound was produced by condensation of 3-hydroxy-4-
methoxybenzaldehyde with the polymer terminated with an amino group. The
resulting compounds' structure was confirmed using FT-IR, elemental analysis,
TGA and XRD. All synthesized compounds were identified and characterized. The 
prepared S-BPHS compound showed potential antioxidant and antimicrobial activities.

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