A Comprehensive Review on Novasomes As Lipid-Based Drug Carriers

Document Type : Narrative Review Article

Authors

Department of Pharmaceutics, Faculty of Pharmacy, Sinai University, Arish Branch, North Sinai 45511, Egypt

Abstract

Background: Novasomes (Novs) are a novel lipid-based drug delivery system
(LBDDS) for enhanced drug delivery. Those systems are composed of surface
active agents (SAA) and free fatty acids (FFA) that self-assemble into spherical
bilayer structures to encapsulate a variety of therapeutic drugs. Novs have been
extensively studied as drug carriers, including antifungals, antibiotics, anti-
inflammatory, and anticancer drugs. They approved better solubility and
permeability, greater therapeutic efficacy, and diminished side effects when
compared to free drug formulations.
Aims of this review: This review provides a thorough outlook, including
novasomal constituents, development techniques, advantages and disadvantages,
variant characterizations, routes of administration, pharmacological applications,
and future prospects in the field of novasomal research.

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